--- title: Folate deficiency and folic acid supplementation description: Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. image: https://azingro.com/hubfs/1054-1200x745.jpg --- [Skip to content](https://azingro.com/news/folate-deficiency-and-folic-acid-supplementation#main-content) [![azingro_logo-1](https://azingro.com/hubfs/azingro_logo-1.svg "azingro_logo-1")](https://azingro.com/) - Company [![](https://azingro.com/hubfs/line_information-circle.svg) History](https://azingro.com/company-history) [![](https://azingro.com/hubfs/line_aim.svg) Mission & Family Values](https://azingro.com/mission-family-values) [![](https://azingro.com/hubfs/line_world.svg) Global Presence](https://azingro.com/global-presence) [![](https://azingro.com/hubfs/awareness-earth-eco-social-awareness-svgrepo-com.svg) Corporate Social Responsibility](https://azingro.com/corporate-social-responsibility) [![](https://azingro.com/hubfs/line_job.svg) Career](https://azingro.com/career) - Products [![](https://azingro.com/hubfs/healthsolutions.png) Health Solutions Our health solutions are products with a **health and/or nutritional benefit** for use in different applications of the food & health industry. - choline – CHOLIFE® - vitamins – AZINVIT® - amino acids - others](https://azingro.com/health-solutions) [![](https://azingro.com/hubfs/technologicalsolutions.png) Technological Solutions Our technological solutions add a **technological function** to food products, such as preserving food from spoilage, improving colour, taste or texture, or the prevention of food from oxidation. - calcium propionate – PROPIMPEX® - preservatives, organic acids & antioxidants](https://azingro.com/technological-solutions) [![](https://azingro.com/hubfs/naturalsolutions.png) Natural Solutions Azingro's natural solutions give our customers the opportunity to apply **clean label** and **100% natural products** in their food applications. - natural mold inhibitor](https://azingro.com/natural-solutions) - [Quality](https://azingro.com/food-safety-quality) - [News](https://azingro.com/news) - [Events](https://azingro.com/events) - [Contact](https://azingro.com/contact) - This is a search field with an auto-suggest feature attached. - There are no suggestions because the search field is empty. # Folate deficiency and folic acid supplementation by [Azingro](https://azingro.com/news/author/azingro) on May 15, 2018 Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. The findings of the Hungarian intervention (randomized double-blind and cohort controlled) trials indicated that periconceptional folic acid (FA)-containing multivitamin supplementation prevented the major proportion (about 90%) of neural-tube defects (NTD) as well as a certain proportion (about 40%) of congenital heart defects. Finally the benefits and drawbacks of three main practical applications of folic acid/multivitamin treatment such as (i) dietary intake; (ii) periconceptional supplementation; and (iii) flour fortification are discussed. The conclusion arrived at is indeed confirmation of Benjamin Franklin’s statement: “An ounce of prevention is better than a pound of care”. Click the image below to read the report. 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